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Tocris Bioscience™ RQ 00203078
Potent and selective TRPM8 antagonist; orally active
Supplier: Tocris Bioscience™ 5388/50
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Description
RQ 00203078 is a potent TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively). Exhibits >350-fold selectivity for TRPM8 over TRPV4, TRPV1 and TRPA1. Reduces HSC3 and HSC4 oral squamous carcinoma cell migration and invasion in vitro. Also attenuates icilin -induced wet dog shakes in rats. Orally active.Specifications
>98% | |
554.85 | |
50 mg |
RQ 00203078 | |
RQ 00203078 |
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