Tocris™ RQ 00203078

Potent and selective TRPM8 antagonist; orally active

Manufacturer: Tocris™ 5388/10

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Catalog No. 53-881-0

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For Research Use Only


    Description RQ 00203078
    Molecular Weight 554.85
    Purity >98
    Quantity 10mg
    Product Type RQ 00203078

    Potent TRPM8 antagonist (IC50 values are 5.3 and 8.3nM for rat and human channels respectively). Exhibits >350-fold selectivity for TRPM8 over TRPV4, TRPV1 and TRPA1. Reduces HSC3 and HSC4 oral squamous carcinoma cell migration and invasion in vitro. Also attenuates icilin-induced wet dog shakes in rats. Orally active.

    • Chemical Name: 4-[[[3-Chloro-5-(trifluoromethyl)-2-pyridinyl][[4-(trifluoromethoxy)phenyl]methyl]amino]sulfonyl]benzoic acid
    • Formula: C21H13ClF6N2O5S
    • CAS Number: 1254205-52-1
    • Solubility: Soluble to 100mM in DMSO and to 100mM in ethanol
    • Purity: >98

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