Tocris™ RQ 00203078

Potent and selective TRPM8 antagonist; orally active

Manufacturer: Tocris™ 5388/10

 View more versions of this product

Catalog No. 53-881-0

  Check Availability
Add to Cart


For Research Use Only


    Description RQ 00203078
    Molecular Weight 554.85
    Purity >98
    Quantity 10mg
    Product Type RQ 00203078

    Potent TRPM8 antagonist (IC50 values are 5.3 and 8.3nM for rat and human channels respectively). Exhibits >350-fold selectivity for TRPM8 over TRPV4, TRPV1 and TRPA1. Reduces HSC3 and HSC4 oral squamous carcinoma cell migration and invasion in vitro. Also attenuates icilin-induced wet dog shakes in rats. Orally active.

    • Chemical Name: 4-[[[3-Chloro-5-(trifluoromethyl)-2-pyridinyl][[4-(trifluoromethoxy)phenyl]methyl]amino]sulfonyl]benzoic acid
    • Formula: C21H13ClF6N2O5S
    • CAS Number: 1254205-52-1
    • Solubility: Soluble to 100mM in DMSO and to 100mM in ethanol
    • Purity: >98

  • Description & Specifications

Related Products

Product Content Feedback

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit