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RRP8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 201291AP

Catalog No. 50-173-2719


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Description

Description

Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at  ft.Lys-9 ft. (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Specifications

Specifications

RRP8
0.5 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
O43159, Q5U4F0, Q9DB85
Cerebral protein 1, KIAA0409, Nucleomethylin, RRP8
Rabbit
IgG
150 μL
-20°C
Primary
101867, 23378, 308911
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
RRP8
Liquid
Rrp8
RRP8 Fusion Protein Ag13994
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Documents
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