RRP8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 201291AP
DescriptionEssential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at ft.Lys-9 ft. (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|O43159, Q5U4F0, Q9DB85|
|Cerebral protein 1, KIAA0409, Nucleomethylin, RRP8|
|101867, 23378, 308911|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|RRP8 Fusion Protein Ag13994|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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