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RSPO1 Mouse anti-Human, Clone: OTI11A9, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526680

Catalog No. PIMA526680


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Description

Description

RSPO1 is a member of a family of secreted growth factors that can operate through the canonical Wnt signaling pathway by stabilizing the intracellular beta-catenin, thereby regulating functions mediated by beta-catenin such as cell fate decisions and embryonic patterning. RSPO1 was recently identified through linkage analysis to be involved in sex determination and mammalian ovarian development. RSPO1 is thought to regulate cellular responsiveness to Wnt ligands by modulating the cell-surface expression of the Wnt co-receptor LRP6 by interfering with the DKK/Kremen-mediated internalization of LRP6 through an interaction with Kremen, resulting in increased LRP6 cell-surface levels. At least two isoforms of RSPO1 are known to exist. RSPO1 antibody will not cross-react with RSPO family members.
Specifications

Specifications

RSPO1
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q2MKA7
RP11-566C13.1, CRISTIN3, RSPO; R-spondin homolog; R-spondin-1; roof plate-specific spondin-1
Mouse
IgG2b
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
284654
Immunohistochemistry (Paraffin), Western Blot
OTI11A9
Unconjugated
RSPO1
Liquid
RSPO1
Human recombit protein fragment corresponding to amino acids 21-263 of RSPO1 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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