RTN1 (Isoform RTN1-C) Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 150481AP
This antibody is raised against the full-length protein of human RTN1-C.Reticulon-1 was formerly designated NSP for Neuroendocrine-Specific-Protein, because it is specifically expressed in neural and neuroendocrine tissues. The NSP-gene has been mapped by fluorescence in situ hybridization to human chromosome 14q21-q22. The NSP-gene encodes three overlapping proteins, i. e. reticulon-1A (NSP-A), reticulon-1B (NSP-B), and reticulon-1C (NSP-C). These proteins were found to be anchored to membranes of the endoplasmic reticulum through their common carboxy-terminal regions. Reticulon-1A is a protein with a molecular weight of ~135 kDa, which occurs in various isoforms presumably depending on the degree of phosphorylation of serine residues. In lung cancer diagnosis Reticulon-1A appeared to be a reliable marker for the detection of neuroendocrine differentiation, since most of the small cell lung carcinoma (SCLC) and carcinoid tumors showed expression of Reticulon-1A. Reticulon-1B is a phosphoprotein with a MW of 45 kDa and is restricted to the lung cancer cell line NCI-H82. Reticulon-1B is so far not found in human tissues. Reticulon-1C is a protein with a MW of 23 kDa which is not phosphorylated and is found with Reticulon-1A in SCLC (cell lines) and not in non-SCLC (cell cultures).
|RTN1 (Isoform RTN1-C)|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|Q16799, Q64548, Q8K0T0|
|NSP, NSP-C, reticulon 1, RTN1, RTN1-C|
|104001, 116644, 6252|
|Immunohistochemistry (Paraffin), Western Blot|
|RTN1 (Isoform RTN1-C) Fusion Protein Ag7031|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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