Tocris™ RU-SKI 43 hydrochloride

Hedgehog acyltransferase (Hhat) inhibitor; cell permeable

Manufacturer: Tocris™ 4886/10

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Catalog No. 48-861-0

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For Research Use Only


    Product Type RU-SKI 43 hydrochloride
    Inhibitors RU-SKI 43 hydrochloride
    Purity >98
    Molecular Weight 423.01
    Quantity 10mg

    Hedgehog acyltransferase (Hhat) inhibitor (IC50 = 850nM). Inhibits Sonic Hedgehog N (ShhN) palmitoylation in vitro. Has no effect on porcupine-induced fatty acid acylation of Wnt39a. Attenuates pancreatic cancer cell proliferation. Cell permeable.

    • Chemical Name: 2-((2-Methylbutyl)amino)-1-(4-((3-methylphenoxy)methyl-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanone hydrochloride
    • Formula: C22H30N2O2S.HCl
    • Solubility: Soluble to 100mM in DMSO
    • Purity: >98

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