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Rubicon Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 214441AP

Catalog No. 50-173-3421


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Description

Description

Two Beclin-1-interacting proteins, the run domain Beclin-1 interacting and cysteine-rich containing protein (Rubicon) and ATG14L, reciprocally regulate autophagy at different stages. Knockdown of Rubicon caused enhancement of autophagy while that of ATG14L caused a defect in autophagosome formation. Rubicon functions as part of a Beclin-1-PIK3C3-containing autophagy complex and is also an essential, positive regulator of the NAPDH oxidase complex. Upon microbial infection or TLR2 activation, Rubicon interacts with the CYBA subunit of the NAPDH oxidase complex, leading to a burst of reactive oxygen species and inflammatory cytokines.
Specifications

Specifications

Rubicon
0.47 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q80U62, Q92622
Baron, KIAA0226, RUBCN, Rubicon
Rabbit
IgG
150 μL
-20°C
Primary
100502698, 303885, 9711
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
RUBCN
Liquid
Rubcn
Rubicon Fusion Protein Ag13715
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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