RUNX1T1 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA540064
DescriptionETO is a transcriptional regulator which belongs to the myeloid translocation gene family. ETO exerts its function by interaction with transcription factors bound to promoters and binding to histone deacetylases. It recruits a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukaemia. This translocation produces a chimeric gene made up of the 5 ft.-region of AML1and the 3 ft.-region of the ETO gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation.
|whole serum with 0.05% sodium azide|
|RUNX1T1, AML1T1, CBFA2T1, CDR, MTG8, ZMYND2|
|ChIP assay, ChIP-sequencing, ELISA|
|Two KLH-conjugated synthetic peptides containing sequences from the N-terminal and the central region of the protein, respectively corresponding to human ETO (runt-related transcription factor 1; translocated to, 1 (cyclin D-related).|
|-20°C or -80°C if preferred|
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