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RUNX1T1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA540064

Catalog No. PA540064


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Description

Description

ETO is a transcriptional regulator which belongs to the myeloid translocation gene family. ETO exerts its function by interaction with transcription factors bound to promoters and binding to histone deacetylases. It recruits a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukaemia. This translocation produces a chimeric gene made up of the 5 ft.-region of AML1and the 3 ft.-region of the ETO gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation.
Specifications

Specifications

RUNX1T1
Polyclonal
whole serum with 0.05% sodium azide
Q06455
RUNX1T1, AML1T1, CBFA2T1, CDR, MTG8, ZMYND2
Rabbit
IgG
RUO
Antibody
Polyclonal
Human
ChIP assay, ChIP-sequencing, ELISA
Unconjugated
RUNX1T1
Liquid
RUNX1T1
Two KLH-conjugated synthetic peptides containing sequences from the N-terminal and the central region of the protein, respectively corresponding to human ETO (runt-related transcription factor 1; translocated to, 1 (cyclin D-related).
100 μL
-20°C or -80°C if preferred
Primary
862
Documents
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