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RUNX1T1 Mouse anti-Human, Clone: OTI1H1, liquid, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner TA504703

Catalog No. 50-167-5334


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Description

Description

RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5 ft.-region of the RUNX1 gene fused to the 3 ft.-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5 ft.-region of the RUNX1 gene fused to the 3 ft.-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.
Specifications

Specifications

RUNX1T1
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Q06455
AML1-MTG8, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
862
Immunocytochemistry, Immunofluorescence, Western Blot
OTI1H1
Unconjugated
RUNX1T1
Liquid
RUNX1T1
Full length human recombit protein of human RUNX1T1 produced in HEK293T cell.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
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