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Medchemexpress LLC Ruxolitinib phosphate (INCB018424 phosphate) | 1092939-17-7 | 99.97% | 10 MM * 1 ML
SDP

Supplier:  Medchemexpress LLC HY5085810MM/1ML

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Ruxolitinib phosphate is a potent JAK1/2 inhibitor with IC50s of 3.3 nM for JAK1 and 2.8 nM for JAK2, demonstrating over 130-fold selectivity compared to JAK3. It potently and selectively inhibits JAK2V617F-mediated signaling and proliferation.

  • Inhibits the growth of HEL cells with an EC50 of 186 nM.
  • Significantly increases apoptosis in the Ba/F3-EpoR-JAK2V617F cell system.
  • Inhibits hematopoietic progenitor cell proliferation in primary Myeloproliferative Neoplasm (MPN) patient samples.

Catalog No. 50-003-58398


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