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RWDD3 Rabbit anti-Human, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 227371AP

Catalog No. 50-173-3936



Description

Description

RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune-inflammatory signals. RWDD3 increases Ikappa-Beta sumoylation and stability. In addition, RWDD3 inhibits TNF-a-induced kappaB-LUC (Luciferase) reporter activity, showing the functional consequence of Ikappa-Beta increased stability. RSUME-enhanced sumoylation of Ikappa-Beta leads to the inhibition of NF-kappa-Beta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.
Specifications

Specifications

RWDD3
0.55 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q9Y3V2
RSUME, RWD domain containing 3, RWDD3
Rabbit
IgG
150 μL
-20°C
Primary
25950
Immunohistochemistry (Paraffin)
Unconjugated
RWDD3
Liquid
RWDD3
RWDD3 Fusion Protein Ag18674
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Documents
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