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RYBP Mouse anti-Human, Clone: OTI1B2, liquid, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner TA504650

Catalog No. 50-167-5296


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Description

Description

RYBP involves component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A  ft.Lys-119 ft., rendering chromatin heritably changed in its expressibility. Component of a PRC1-like complex that mediates monoubiquitination of histone H2A  ft.Lys-119 ft. on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A  ft.Lys-119 ft. by recruiting the complex to target sites. Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3.
Specifications

Specifications

RYBP
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Q8N488
AAP1, APAP-1, DEDAF, YEAF1
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
23429
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI1B2
Unconjugated
RYBP
Liquid
RYBP
Full length human recombit protein of human RYBP produced in E.coli.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
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