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RYR2 Rabbit anti-Human, Mouse, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 197651AP

Catalog No. 50-173-2532


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Description

Description

This antibody detects a band at ~250 kDa which has been reported.

Dihydropyridine receptor (DHPR) is a surface membrane protein critical for the excitation-contraction coupling of striated muscle. DHPR and the sarcoplasmic reticulum ryanodine receptor (RyR) are two key components of the intracellular junctions, where depolarization of the surface membrane is converted into the release of Ca2+ from internal stores. The alpha1-subunit of the DHPR contains a cytoplasmic loop which is thought to be involved in the interactions with RyR. Phosphorylation of the DHPR alpha1-subunit is also thought to play a role in the functional interaction of DHPR and RyR. Mutation in DHPR alpha1 results in excitation-contraction uncoupling, leading to muscular dysgenesis, a complete inactivity in developing skeletal muscles. Cells that do not express RyR also lack excitation-contraction coupling and exhibit a severalfold reduction in Ca2+ current density.
Specifications

Specifications

RYR2
0.33 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
E9Q401, Q92736
ARVC2, ARVD2, ryanodine receptor 2 (cardiac), ryanodine receptor 2, cardiac, RYR2, VTSIP
Rabbit
IgG
150 μL
-20°C
Primary
20191, 6262
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
RYR2
Liquid
RYR2
Peptide
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
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