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S100A12 Mouse anti-Human, Clone: OTI1D1, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525436

Catalog No. PIMA525436


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Description

Description

S100A12 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A12 is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. S100A12 is also a ligand for RAGE. Interaction with RAGE on mononuclear phagocytes, lymphocytes and endothelium triggers cellular activation. Nuclear factor kappa B, a key transcription factor for inflammatory events, is activated by S100A12/RAGE. S100A12 has also been shown to have anti-microbial properties.
Specifications

Specifications

S100A12
Monoclonal
0.68 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P80511
CAAF1;CAGC;Calcitermin;Calcium binding protein in amniotic fluid;Calcium-binding protein in amniotic fluid 1;Calgranulin C;Calgranulin related protein;Calgranulin-C;CGRP;EN RAGE;EN-RAGE;ENRAGE;Extracellular newly identified RAGE-binding protein;MRP6;Neutrophil S100 protein;p6;Protein S100 A12;S100 calcium binding protein A12;S100 calcium-binding protein A12;S100A12;S10AC_HUMAN;
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
6283
Immunohistochemistry (Paraffin), Western Blot
OTI1D1
Unconjugated
S100A12
Liquid
S100A12
Full length human recombit protein of S100A12 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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