S1P1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific OPA115004

Catalog No. OPA115004

Description

OPA1-15004 detects S1P1 from human samples. OPA1-15004 has been successfully used in Western blotting and immunohistochemistry (paraffin) procedures. Positive Control: Heart, Vessel The OPA1-15004 immunogen is a synthetic peptide, KLH conjugated, corresponding to the C-terminal domain of human S1P1. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.

S1P1 is a G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that is coupled to the G(i) subclass of heteromeric G proteins. S1P1 signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. It plays an important role in cell migration via its role in the reorganization of the actin cytoskeleton and formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. S1P1 is required for normal chemotaxis toward sphingosine 1-phosphate, normal embryonic heart development, and normal cardiac morphogenesis.

Specifications

• Antigen: S1P1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene Accession No.: P21453
• Gene Symbols: S1PR1
• Immunogen: Synthetic peptide, KLH conjugated, corresponding to the C-terminal domain of human S1P1.
• Quantity: 25 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Gene: S1PR1
• Gene Alias: Sphingolipid Receptor 1, Endothelial Differentiation Gene 1, EDG1, S1PR1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1901
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid