UBA2 Mouse anti-Canine, Human, Non-human primate, Rat, Clone: OTI4A3, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA525437
DescriptionUbiquitin is covalently attached to target proteins by a multienzymatic system consisting of E1 (ubiquitin-activating), E2 (ubiquitin-conjugating), and E3 (ubiquitin-ligating) enzymes. NEDD8, a ubiquitin-like protein, is conjugated to proteins in a manner analogous to ubiquitinylation. beta-amyloid precursor protein-binding protein-1 (APPBP1) can bind to NEDD8 in rabbit reticulocyte lysates. However, since APPBP1 shows similarity to only the N-terminal domain of an E1 enzyme, it must interact with a protein showing similarity to the C-terminal region of E1s. By searching sequence databases, a cDNAs encoding UBA3 was identified as the human homolog of yeast Uba3. The predicted 442-amino acid UBA3 protein shares 43% sequence identity with yeast Uba3. In vitro, UBA3 formed a complex with APPBP1 and a thioester linkage with NEDD8. APPBP1/UBA3 complex may function as an E1-like enzyme for the activation of NEDD8.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|HRIHFB2115, ARX, SAE2; SUMO-1 activating enzyme subunit 2; SUMO-activating enzyme subunit 2; SUMO1 activating enzyme subunit 2; UBA2, ubiquitin-activating enzyme E1 homolog; anthracycline-associated resistance ARX; ubiquitin-like 1-activating enzyme E1B|
|-20° C, Avoid Freeze/Thaw Cycles|
|10054, 308508, 476490, 705808|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of UBA2 produced in HEK293T cell|
|Canine, Human, Non-human primate, Rat|
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