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UBA2 Mouse anti-Canine, Human, Non-human primate, Rat, Clone: OTI4A3, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525437

Catalog No. PIMA525437


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Description

Description

Ubiquitin is covalently attached to target proteins by a multienzymatic system consisting of E1 (ubiquitin-activating), E2 (ubiquitin-conjugating), and E3 (ubiquitin-ligating) enzymes. NEDD8, a ubiquitin-like protein, is conjugated to proteins in a manner analogous to ubiquitinylation. beta-amyloid precursor protein-binding protein-1 (APPBP1) can bind to NEDD8 in rabbit reticulocyte lysates. However, since APPBP1 shows similarity to only the N-terminal domain of an E1 enzyme, it must interact with a protein showing similarity to the C-terminal region of E1s. By searching sequence databases, a cDNAs encoding UBA3 was identified as the human homolog of yeast Uba3. The predicted 442-amino acid UBA3 protein shares 43% sequence identity with yeast Uba3. In vitro, UBA3 formed a complex with APPBP1 and a thioester linkage with NEDD8. APPBP1/UBA3 complex may function as an E1-like enzyme for the activation of NEDD8.
Specifications

Specifications

UBA2
Monoclonal
0.41 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q9UBT2
HRIHFB2115, ARX, SAE2; SUMO-1 activating enzyme subunit 2; SUMO-activating enzyme subunit 2; SUMO1 activating enzyme subunit 2; UBA2, ubiquitin-activating enzyme E1 homolog; anthracycline-associated resistance ARX; ubiquitin-like 1-activating enzyme E1B
Mouse
IgG2a
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
10054, 308508, 476490, 705808
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI4A3
Unconjugated
UBA2
Liquid
UBA2
Full length human recombit protein of UBA2 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Canine, Human, Non-human primate, Rat
Documents
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