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SAFB Mouse anti-Human, Clone: 8E6, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524869

Catalog No. PIMA524869


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Description

Description

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a  ft.transcriptosome complex ft. in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.
Specifications

Specifications

SAFB
Monoclonal
Unconjugated
SAFB
Liquid
SAFB
Recombit full length Human SAFB-1.
Antigen affinity chromatography
RUO
Antibody
Monoclonal
Human
Immunocytochemistry, Immunofluorescence, Western Blot
8E6
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Q15424
HSP27 estrogen response element-TATA box-binding protein; HAP; HET; SAFB1; SAF-B1
Mouse
IgG1
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
6294
Documents
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