Invitrogen™ SART1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA556664

Catalog No. PIPA556664

Description

Immunogen sequence: RRVKKIRKKE KEVVVRADDL LPLGDQTQDG DFGSRLRGRG RRRVSEVEEE KEPVPQPLPS DDTRVENMDI SDEEEGGAPP PGSPQVLEED EAELELQKQL EKG Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 83%.

This gene encodes two proteins, the SART1protein expressed in the nucleus of the majority of proliferating cells, and the SART1protein expressed in the cytosol of epithelial cancers. The SART1protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.

Specifications

• Antigen: SART1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SART1
• Gene Alias: Ara1; Haf; Hom s 1; HOMS1; hSART-1; hSnu66; Hypoxia-associated factor; IgE autoantigen; MGC2038; mSART-1; rSART-1; Sart1; SART-1; SART1(259) protein; SART1(800) protein; SART1259; small nuclear ribonucleoprotein 110kDa (U4/U6.U5); SNRNP110; Snu66; SNU66 homolog; squamous cell carcinoma antigen recognised by T cells; squamous cell carcinoma antigen recognized by T cells; squamous cell carcinoma antigen recognized by T cells 1; squamous cell carcinoma antigen recognized by T-cells 1; U4/U6.U5 tri-snRNP-associated 110 kDa protein; U4/U6.U5 tri-snRNP-associated protein 1; U5-110K
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20227, 29678, 9092
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O43290, Q5XIW8, Q9Z315
• Gene Symbols: SART1
• Immunogen: Recombinant protein corresponding to Human SART1. Recombinant protein control fragment (Product #RP-95144).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG