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SATB1 Mouse anti-Human, Mouse, Rat, Clone: OTI3E12, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524958

Catalog No. PIMA524958


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Description

Description

Human special AT-rich sequence-binding protein-1 (SATB1) is a nuclear matrix/scaffold-associated region DNA-binding protein, predomitly expressed in the thymus and pre-B cells. Like its homolog SATB2, SATB1 selectively binds double-stranded, special AT-rich DNA sequences in which one strand exclusively consists of well-mixed A, T, and C nucleotides. SATB1 contains a dimerization domain that shares similarity with the PDZ motif, identified as an indispensable element for high-affinity binding of SATB1 to DNA. SATB1 constitutes a functional nuclear architecture that has a  ft.cage-like ft. protein distribution surrounding heterochromatin and regulates gene expression through chromatin remodeling/HDAC (histone deacetylase complex) and transcription factors recruitment. SATB1 functions as a  ft.genome organizer ft. essential for proper T-cell development. Recent studies show that SATB1 is necessary for breast cancer cells to become metastatic, and when ectopically expressed in non-metastatic cells, can induce invasive activity in vivo. At least two isoforms of SATB1 are known to exist.
Specifications

Specifications

SATB1
Monoclonal
0.93 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q60611, Q01826
SATB1; SATB homeobox 1; DNA-binding protein SATB1; special AT-rich sequence binding protein 1; special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA′s)
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
6304, 0, 20230
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI3E12
Unconjugated
SATB1
Liquid
SATB1
Full length human recombit protein of SATB1 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Documents
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