SATB1 Mouse anti-Human, Mouse, Rat, Clone: OTI3E12, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA524958
DescriptionHuman special AT-rich sequence-binding protein-1 (SATB1) is a nuclear matrix/scaffold-associated region DNA-binding protein, predomitly expressed in the thymus and pre-B cells. Like its homolog SATB2, SATB1 selectively binds double-stranded, special AT-rich DNA sequences in which one strand exclusively consists of well-mixed A, T, and C nucleotides. SATB1 contains a dimerization domain that shares similarity with the PDZ motif, identified as an indispensable element for high-affinity binding of SATB1 to DNA. SATB1 constitutes a functional nuclear architecture that has a ft.cage-like ft. protein distribution surrounding heterochromatin and regulates gene expression through chromatin remodeling/HDAC (histone deacetylase complex) and transcription factors recruitment. SATB1 functions as a ft.genome organizer ft. essential for proper T-cell development. Recent studies show that SATB1 is necessary for breast cancer cells to become metastatic, and when ectopically expressed in non-metastatic cells, can induce invasive activity in vivo. At least two isoforms of SATB1 are known to exist.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|SATB1; SATB homeobox 1; DNA-binding protein SATB1; special AT-rich sequence binding protein 1; special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA′s)|
|-20° C, Avoid Freeze/Thaw Cycles|
|6304, 0, 20230|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of SATB1 produced in HEK293T cell|
|Human, Mouse, Rat|
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