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SATB2 Mouse anti-Human, Clone: OTI7E11, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526490

Catalog No. PIMA526490


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Description

Description

DNA-binding protein SATB2 binds to DNA at the nuclear matrix- or scaffold associated regions. It is thought to recognize the sugar-phosphate structure of double-stranded DNA. SATB2 is a transcription factor controlling nuclear gene expression by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. It also acts as a docking site for several chromatin remodeling enzymes by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. SATB2 is required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes - probably by modulating BCL11B expression. It is a repressor of Ctip2 and a regulatory determit of corticocortical connections in the developing cerebral cortex. Mutations in the gene are associate with cleft palate isolated (CPI).
Specifications

Specifications

SATB2
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q9UPW6
FLJ21474, FLJ32076, KIAA1034, MGC119474, MGC119477, DNA-binding protein SATB2; SATB family member 2; special AT-rich sequence-binding protein 2
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
23314
Immunohistochemistry (Paraffin), Western Blot
OTI7E11
Unconjugated
SATB2
Liquid
SATB2
Human recombit protein fragment corresponding to amino acids 447-733 of SATB2 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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