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  8. SB 203580, Tocris Bioscience™

SB 203580, Tocris Bioscience™

Catalog Number 120210
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Quantity:
1 mg
10 mg
50 mg
This item is not returnable. View return policy
152121-47-6
C21H16FN3OS
377.437
CDMGBJANTYXAIV-UHFFFAOYSA-N
4-4-4-fluorophenyl-2-4-methylsulfinyl phenyl-1h-imidazol-5-yl pyridine, 4-4-fluorophenyl-2-4-methylsulfinyl phenyl-5-4-pyridyl-1h-imidazole, 4-4-fluorophenyl-2-4-methylsulfinylphenyl-5-4-pyridyl-1h-imidazole, chembl10, 4-4-fluorophenyl-2-4-methylsulfinylphenyl-5-4-pyridyl 1h-imidazole, insolution sb 203580, 4-4-4-fluorophenyl-2-4-methylsulfinylphenyl-1h-imidazol-5-yl pyridine, unii-ws78qr6dsv, 4-5-4-fluorophenyl-2-4-methylsulfinyl phenyl-1h-imidazol-4-yl pyridine, pyridine, 4-5-4-fluorophenyl-2-4-methylsulfinyl phenyl-1h-imidazol-4-yl
176155
4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine
CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F
This item is not returnable. View return policy
152121-47-6
C21H16FN3OS
377.437
CDMGBJANTYXAIV-UHFFFAOYSA-N
4-4-4-fluorophenyl-2-4-methylsulfinyl phenyl-1h-imidazol-5-yl pyridine, 4-4-fluorophenyl-2-4-methylsulfinyl phenyl-5-4-pyridyl-1h-imidazole, 4-4-fluorophenyl-2-4-methylsulfinylphenyl-5-4-pyridyl-1h-imidazole, chembl10, 4-4-fluorophenyl-2-4-methylsulfinylphenyl-5-4-pyridyl 1h-imidazole, insolution sb 203580, 4-4-4-fluorophenyl-2-4-methylsulfinylphenyl-1h-imidazol-5-yl pyridine, unii-ws78qr6dsv, 4-5-4-fluorophenyl-2-4-methylsulfinyl phenyl-1h-imidazol-4-yl pyridine, pyridine, 4-5-4-fluorophenyl-2-4-methylsulfinyl phenyl-1h-imidazol-4-yl
176155
4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine
CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F

Description

Selective inhibitor of p38 MAPK

SB 203580 is a selective inhibitor of p38 MAPK (IC50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively). Displays 100-500-fold selectivity over LCK, GSK-3β and PKBα. Shown to inhibit IL-2-induced T cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase. Enhances clonal growth of skin epithelial progenitor cells; stimulates neural stem cell (NSC) proliferation. SB 203580 is an essential component of medium for maintaining stem cells in naive pluripotent state and can be used to promote expansion of HSCs ex vivo.

Water-soluble Salt also available.

Quantity 10 mg
Formula Weight 377.44
Percent Purity >98%
Chemical Name or Material SB 203580

Safety and Handling

Recommended Storage Store at +4°C
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