Potent and selective CCR3 antagonist (IC50 = 39nM). Displays 250-fold selectivity for CCR3 over other chemokine receptors, including CXCR1, CXCR2, CCR1 and CCR7 (IC50 >27µM). Inhibits calcium mobilization induced by MCP-4, eotaxin-2 and eotaxin in RBL-2H3 cells transfected with CCR3 (IC50 values are 80, 90 and 210nM respectively).
Chemical Name: N-Benzoyl-4-nitroaniline ethyl ester
CAS Number: 58816-69-6
Solubility: Soluble to 100mM in DMSO and to 20mM in ethanol
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