Tocris™ SB 328437

Potent and selective CCR3 antagonist

Manufacturer: Tocris™ 3650/10

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Catalog No. 36-501-0R

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Disclaimers:

For Research Use Only


    Specifications

    Product Type SB 328437
    Inhibitors SB 328437
    Purity >99
    Molecular Weight 378.38
    Quantity 10mg

    Potent and selective CCR3 antagonist (IC50 = 4nM). Displays > 2500-fold selectivity over C5aR, LTD4, CCR7, CXCR1 and CXCR2 receptors. Inhibits eotaxin-, eotaxin-2- and MCP-4-induced Ca2+ mobilization (IC50 values are 38, 35 and 20nM respectively) and inhibits eotaxin-, eotaxin-2- and MCP-4-induced eosinophil chemotaxis with similar potencies.

    • Chemical Name: N-(1-Naphthalenylcarbonyl)-4-nitro-L-phenylalanine methyl ester
    • Formula: C21H18N2O5
    • CAS Number: 247580-43-4
    • Solubility: Soluble to 100mM in DMSO
    • Purity: >99

  • Description & Specifications

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