Tocris SB 525334
Selective inhibitor of TGF-betaRI
Manufacturer: Tocris 3211/10
DescriptionSelective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50 = 14.3nM). Inhibits TGF-β1-induced smad2/3 nuclear localization and TGF-βRI-induced mRNA expression in kidney cells. Attenuates bleomycin-induced pulmonary fibrosis.
- Chemical Name: 6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline
- Formula: C21H21N5
- CAS Number: 356559-20-1
- Solubility: Soluble to 100mM in DMSO and to 100mM in 1eq. HCl
- Purity: >97
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