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Tocris Bioscience™ SB 612111 hydrochloride

Selective NOP antagonist

Supplier:  Tocris Bioscience™ 3573/10

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Catalog No. 35-731-0R


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Description

Description

SB 612111 hydrochloride is a selective NOP receptor antagonist (Ki values are 0.33, 57.6, 160.5 and 2109 nM for NOP, μ-, κ- and δ-receptors respectively). Antagonizes the pronociceptive action of nociceptin (Cat. No. 0910) in an acute pain model. Potentiates the action of morphine in morphine-tolerant animals and blocks hyperalgesia in an inflammatory pain model.
Specifications

Specifications

97%
-20°C
SB 612111 hydrochloride
SB 612111 hydrochloride
(5 S,7 S)-7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5 H-benzocyclohepten-5-ol hydrochloride
10 mg
M.W. (Observed): 454.86
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