Tocris™ SB 743921 hydrochloride

Potent kinesin spindle protein (KSP) inhibitor

Manufacturer: Tocris™ 5109/50

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Catalog No. 51-095-0

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Disclaimers:

For Research Use Only


    Specifications

    Product Type SB 743921 hydrochloride
    Inhibitors SB 743921 hydrochloride
    Purity >98
    Molecular Weight 553.52
    Quantity 50mg

    Potent kinesin spindle protein (KSP) inhibitor (Ki = 0.1nM). Induces cell mitotic arrest and apoptosis in vitro. Inhibits the growth of a range of tumor cells in vitro, including colon (HCT 116), prostate (PC-3) and leukemia (K-562) cancer cell lines. Causes tumor regression in human tumor xenograft models in vivo, including colon (Colo205), lung (H69) and breast (MCF7) cancer cell xenografts.

    • Chemical Name: N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-4H-1-benzopyran-2-yl]-2-methylpropyl]-4-methylbenzamide hydrochloride
    • Formula: C31H33ClN2O3.HCl
    • CAS Number: 940929-33-9
    • Solubility: Soluble to 100mM in DMSO
    • Purity: >98

  • Description & Specifications

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