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SCF Mouse anti-Human, Clone: OTI6E5, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526329

Catalog No. PIMA526329


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Description

Description

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
Specifications

Specifications

SCF
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P21583
DKFZp686F2250, FPH2, KL-1, Kitl, MGF, SCF, SF, SHEP7, c-Kit ligand; familial progressive hyperpigmentation 2; kit ligand; mast cell growth factor; steel factor; stem cell factor
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
4254
Immunohistochemistry (Paraffin), Western Blot
OTI6E5
Unconjugated
KITLG
Liquid
KITLG
Full length human recombit protein of KITLG produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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