Tocris™ SCH 51344

Potent MTH1 inhibitor

Manufacturer: Tocris™ 5280/10

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Catalog No. 52-801-0

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For Research Use Only


    Quantity 10mg
    Product Type SCH 51344
    Inhibitors SCH 51344
    Purity >99
    Molecular Weight 316.35

    Potent MTH1 inhibitor (Kd = 49nM). Inhibits Ras-induced malignant transformation and increases α-actin promoter-driven CAT activity in Ras-transformed cells. Has no effect on Ras-induced ERK and JNK activation. Inhibits Ras-induced membrane ruffling in REF-52 fibroblasts and blocks anchorage-independent growth of Ras-transformed tumor cell lines. Also induces DNA damage in SW480 colon cancer cells.

    • Chemical Name: 2-[2-[(6-Methoxy-3-methyl-1H-pyrazolo[3,4-b]quinolin-4-yl)amino]ethoxy]ethanol
    • Formula: C16H20N4O3
    • CAS Number: 171927-40-5
    • Solubility: Soluble to 100mM in DMSO
    • Purity: >99

  • Description & Specifications

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