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  8. SCH 529074, Tocris Bioscience™

SCH 529074, Tocris Bioscience™

Catalog Number 424010
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
922150-11-6
C31H36Cl2N6
563.571
NCAJLQDPTZBGJV-UHFFFAOYSA-N
n'-2-4-bis-4-chlorophenyl methyl piperazin-1-ylmethyl quinazolin-4-yl-n,n-dimethylpropane-1,3-diamine, n3-2-4-bis 4-chlorophenyl methyl-1-piperazinyl methyl-4-quinazolinyl-n1,n1-dimethyl-1,3-propanediamine
12001922
N-[2-[[4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]methyl]quinazolin-4-yl]-N',N'-dimethylpropane-1,3-diamine
CN(C)CCCNC1=NC(=NC2=CC=CC=C21)CN3CCN(CC3)C(C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
This item is not returnable. View return policy
922150-11-6
C31H36Cl2N6
563.571
NCAJLQDPTZBGJV-UHFFFAOYSA-N
n'-2-4-bis-4-chlorophenyl methyl piperazin-1-ylmethyl quinazolin-4-yl-n,n-dimethylpropane-1,3-diamine, n3-2-4-bis 4-chlorophenyl methyl-1-piperazinyl methyl-4-quinazolinyl-n1,n1-dimethyl-1,3-propanediamine
12001922
N-[2-[[4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]methyl]quinazolin-4-yl]-N',N'-dimethylpropane-1,3-diamine
CN(C)CCCNC1=NC(=NC2=CC=CC=C21)CN3CCN(CC3)C(C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

Description

Restores mutant p53 activity

Restores mutant p53 activity. Binds p53 DNA binding domain (Kd = 1-2 μM) and restores wild-type function to many oncogenic mutants by acting as a chaperone. Inhibits ubiquitination of p53 by HDM2. Triggers apoptosis in tumor cell lines and reduces tumor growth in a xenograft model.
Quantity 10 mg
Formula Weight 563.56
Percent Purity >98%
Chemical Name or Material SCH 529074

Safety and Handling

Recommended Storage Store at -20°C
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