SCN1A Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA551019
SCN1A Polyclonal Antibody detects endogenous levels of SCN1A protein.Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddel ft.s syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).
|Synthesized peptide derived from the Internal region of human Na+ CP-pan.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4|
|P35498, A2APX8, P04774|
|FEB3, NAC1, Nav1.1, SCN1, Sodium channel protein type 1 subunit alpha, Sodium channel protein brain I subunit alpha, Sodium channel protein type I subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.1|
|-20° C, Avoid Freeze/Thaw Cycles|
|20265, 6323, 81574|
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