Invitrogen™ SCN2A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5103147

Catalog No. PIPA5103147

Description

Antibody detects endogenous levels of total Na+ CP type II alpha.

Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarize the cell. The alpha subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type II alpha subunits are more abundant along axons. The beta1 subunit of sodium channel type I is expressed in brain, skeletal and cardiac muscle. In the brain, beta1 and beta2 are highly expressed in Purkinje cells, and beta1 is also expressed in the pyramidal cells of the deep cerebellar nuclei. Impaired voltage-gated sodium channels lead to a number of diseases including myotonia.

Specifications

• Antigen: SCN2A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Scn2a
• Gene Alias: 6430408L10; A230052E19Rik; alternative product; BFIC3; BFIS3; BFNIS; Brain Type II; EIEE11; HBA; HBSC II; HBSCI; HBSCII; Na(v)1.2; NAC2; NachII; Nav1.2; RII/RIIA; RIIA sodium channel protein; RNSCPIIR; SCN; Scn2a; Scn2a1; SCN2A2; ScpII; Sodium channel protein brain II subunit alpha; sodium channel protein type 2 subunit alpha; Sodium channel protein type II subunit alpha; sodium channel protein, brain II subunit alpha; sodium channel protein, brain type 2 alpha subunit; sodium channel voltage-gated type II alpha polypeptide; sodium channel, voltage gated, type II alpha subunit; sodium channel, voltage-gated, type 2, alpha 1 polypeptide; sodium channel, voltage-gated, type 2, alpha 1 subunit; sodium channel, voltage-gated, type II, alpha 1; sodium channel, voltage-gated, type II, alpha 1 polypeptide; sodium channel, voltage-gated, type II, alpha 2 polypeptide; sodium channel, voltage-gated, type II, alpha polypeptide 1; sodium channel, voltage-gated, type II, alpha subunit; sodium voltage-gated channel alpha subunit 2; voltage-gated sodium channel subtype II; voltage-gated sodium channel subunit alpha Nav1.2; voltage-gated sodium channel type II alpha subunit
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 110876, 24766, 6326
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P04775, Q99250
• Gene Symbols: Scn2a
• Immunogen: A synthesized peptide derived from human SCN2A(Accession Q99250), corresponding to amino acid residues Q447-S497.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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