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SCN9A Mouse anti-Human, Mouse, Rat, Clone: S68-6, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527664

Catalog No. PIMA527664


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Description

Description

Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddel ft.s syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).
Specifications

Specifications

SCN9A
Monoclonal
1 mg/ml
PBS with 50% glycerol and 0.1% sodium azide; pH 7.4
O08562, Q15858, Q62205
ETHA, hNE Na, NE NA, PN1, SCN9A, voltage gated sodium channel subunit alpha Nav1, peripheral sodium channel 1, neuroendocrine sodium channel
Mouse
IgG1
100 μg
-20°C
Primary
20274, 6335, 78956
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
S68-6
Unconjugated
SCN9A
Liquid
SCN9A
Fusion protein amino acids 1751-1946 (C-terminus) of human Nav1.7
Protein G
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Documents
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