SCN9A Mouse anti-Human, Mouse, Rat, Clone: S68-6, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527664
DescriptionEpithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddel ft.s syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).
|PBS with 50% glycerol and 0.1% sodium azide; pH 7.4|
|O08562, Q15858, Q62205|
|ETHA, hNE Na, NE NA, PN1, SCN9A, voltage gated sodium channel subunit alpha Nav1, peripheral sodium channel 1, neuroendocrine sodium channel|
|20274, 6335, 78956|
|Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot|
|Fusion protein amino acids 1751-1946 (C-terminus) of human Nav1.7|
|Human, Mouse, Rat|
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