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gamma-ENaC Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA551073

Catalog No. PA551073


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Description

Description

SCNN1G Polyclonal Antibody detects endogenous levels of SCNN1G protein.

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Heterotetramer of two alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2. Apical cell membrane; Multi-pass membrane protein. Phosphorylated on serine and threonine residues. Defects in SCNN1G are a cause of Liddle syndrome. It is an autosomal domit disorder characterized by pseudoaldosteronism and hypertension associated with hypokalemic alkalosis. The disease is caused by constitutive activation of the renal epithelial sodium channel.
Specifications

Specifications

gamma-ENaC
Polyclonal
Unconjugated
SCNN1G
Liquid
SCNN1G
Synthesized peptide derived from the Internal region of human ENaC ENaC G.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
ELISA, Western Blot
1 mg/mL
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
P51170, Q9WU39, P37091
SCNN1G, Amiloride-sensitive sodium channel subunit gamma, Epithelial Na(+) channel subunit gamma, ENaCG, Gamma-ENaC, Gamma-NaCH, Nonvoltage-gated sodium channel 1 subunit gamma, SCNEG
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
20278, 24768, 6340
Documents
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