SDHB Mouse anti-Human, Clone: OTI1H6, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526937
DescriptionPart of the succinate dehydrogenase complex, SDHB is a mitochondrial protein that interfaces with the catalysis of succinate dehydrogenase. In many gastrointestinal tumors, SDHB is irregularly expressed, and leads to mutational activation of KIT. This may be as a result of elevated oxidative stress caused by mitochondrial dysfunction. In Dutch populations, there is a higher prevalence of mutations in the SDHB gene, and a higher overall level of hereditary paraganglioma and pheochromocytoma syndromes than in other Europeans. Similar trends in mutations in this gene seem to be related to atherosclerosis in American populations. Overall, the SDHB protein effects multiple cellular metabolism processes and it is not surprisingly linked to metabolism-related cellular dysfunctions.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|SDHB; IP; SDH; SDH1; SDHIP; succinate dehydrogenase complex, subunit B, iron sulfur (Ip); OTTHUMP00000044624; iron-sulfur subunit; FLJ92337; PGL4; SDH2; SDHIP|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of SDHB produced in E.coli|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok