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SDHB Mouse anti-Human, Clone: OTI3F5, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526936

Catalog No. PIMA526936


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Description

Description

Part of the succinate dehydrogenase complex, SDHB is a mitochondrial protein that interfaces with the catalysis of succinate dehydrogenase. In many gastrointestinal tumors, SDHB is irregularly expressed, and leads to mutational activation of KIT. This may be as a result of elevated oxidative stress caused by mitochondrial dysfunction. In Dutch populations, there is a higher prevalence of mutations in the SDHB gene, and a higher overall level of hereditary paraganglioma and pheochromocytoma syndromes than in other Europeans. Similar trends in mutations in this gene seem to be related to atherosclerosis in American populations. Overall, the SDHB protein effects multiple cellular metabolism processes and it is not surprisingly linked to metabolism-related cellular dysfunctions.
Specifications

Specifications

SDHB
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P21912
SDHB; IP; SDH; SDH1; SDHIP; succinate dehydrogenase complex, subunit B, iron sulfur (Ip); OTTHUMP00000044624; iron-sulfur subunit; FLJ92337; PGL4; SDH2; SDHIP
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
6390
Immunohistochemistry (Paraffin), Western Blot
OTI3F5
Unconjugated
SDHB
Liquid
SDHB
Full length human recombit protein of SDHB produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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