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SEC13 Rabbit anti-Human, Mouse, Rat, Clone: 1280C, R&D Systems™

Rabbit Monoclonal Antibody

$125.35 - $329.00

Specifications

Antigen SEC13
Formulation Supplied as a solution in PBS containing BSA, Glycerol and Sodium Azide. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS. with Sodium Azide
Format Purified
Clone 1280C
Applications Western Blot
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
MAB90552SP View Documents R&D Systems
MAB90552SP
25 ug Each for $125.35
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MAB90552100 View Documents R&D Systems
MAB90552100
100 ug Each for $329.00
Add to cart
 
Description

Description

Sec13 is a ubiquitously expressed protein which participates in the formation of vesicles in the COPII complex with Sec23p.Sec24p, Sar1p and Sec31. The COPII vesicle budding complex was first described in the yeast system and was shownto provide coat proteins in the early secretory pathway. Sec13 is recruited to endoplasmic reticulum (ER) membranes where it forms a three dimensionalcuboctahedron cage lattice structure by association with Sec31. This vesicular structure is necessary for ER-Golgi transport. Presenillin-1, which is implicated in early-onset Alzheimer's disease has been shown to interact with Sec13 vesicles. Additionally, Sec13 has been shown to be a component of the Y-shaped Nup107-160 subcomplex of the nuclear pore complex (NPC), and the GATOR2 sub-complex of the GATOR complex.
Specifications

Specifications

SEC13
Purified
Western Blot
Rabbit
Protein A or G purified from hybridoma culture supernatant
RUO
Supplied as a solution in PBS containing BSA, Glycerol and Sodium Azide. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS. with Sodium Azide
1280C
Unconjugated
IgG
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
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