Invitrogen™ SEMA6B Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA547251

Catalog No. PIPA547251

Description

In direct ELISAs, approximately 15% cross-reactivity with recombinant human (rh) Semaphorin 6C is observed, 5% cross-reactivity with rhSemaphorin 6D is observed and less than 1% cross-reactivity with rhSemaphorin 3A, rhSemaphorin 3B, rhSemaphorin 6A, rhSemaphorin 7A, recombinant mouse (rm) Semaphorin 3C, rmSemaphorin 3E, and rmSemaphorin 3F is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

The SEMA6B gene encodes semaphorin 6B, which belongs to the semaphorin family of proteins known for their roles in guiding axonal development and modulating cellular signaling pathways. Semaphorin 6B primarily functions in the nervous system where it influences axonal guidance, neuronal development, and synapse formation through interactions with neuropilin and plexin receptor complexes. These interactions are crucial during neural development, ensuring proper neuronal wiring and the establishment of functional neural circuits. In addition to its key role in neural connectivity, SEMA6B is increasingly recognized for its involvement in immune responses, where it can modulate the activity and migration of immune cells. In cancer biology, altered expression of SEMA6B has been implicated in tumor progression, affecting tumor cell adhesion and migration, thereby influencing metastasis. Research continues to explore the specific mechanisms of SEMA6B's action and how it can be targeted for therapeutic interventions in neural and cancer-related diseases.

Specifications

• Antigen: SEMA6B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SEMA6B
• Gene Alias: Sema; sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B; sema N; Sema VIB; sema Z; SEMA6B; SEMAN; semaphorin 6B; semaphorin VIB; semaphorin Z; semaphorin-6B; semaphorin-6Ba; semaphorin-N; Semaphorin-Z; SEMA-VIB; semaZ; SEM-SEMA-Y; UNQ1907/PRO4353; VIb
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10501, 20359
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry, Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: O54951, Q9H3T3
• Gene Symbols: SEMA6B
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Semaphorin 6B Leu26-Ser603.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG