TSEN34 Mouse anti-Human, Clone: OTI6B3, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527261
DescriptionConstitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5 ft.- and 3 ft.-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2 ft.,3 ft.-cyclic phosphate and 5 ft.-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3 ft.-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3 ft.-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3 ft.-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|LENG5; PCH2C; SEN34; SEN34L; hsSen34; leukocyte receptor cluster (LRC) member 5; leukocyte receptor cluster member 5; tRNA-intron endonuclease Sen34; tRNA-splicing endonuclease subunit Sen34|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of TSEN34 produced in E.coli|
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