SENP1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA588971

Catalog No. PIPA588971

Description

Immunogen sequence: SRCLSSSKNT LKDSLFKNGN SCASQIIGSD TSSSGSASIL TNQEQLSHSV YSLSSYTPDV AFGSKDSGTL HHPHHHHSVP HQPDNLAASN TQSEGSDSVI LLKVKDSQTP TPSSTFFQAE LWIKELTSVY DSRARERLRQ IEEQKALALQ LQNQRLQERE HSVHDSVELH LRVPLEKEIP VTVVQETQKK GHKLTDSEDE F; Positive Samples: BxPC-3, HT-29, HepG2, HeLa, Mouse testis, Mouse thymus, Rat testis; Cellular Location: Cytoplasm, Nucleus

SENP1 is a protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. SENP deconjugates SUMO1 from HIPK2 and from HDAC1, which decreases the transcriptional repression activity of the latter.

Specifications

• Antigen: SENP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SENP1
• Gene Symbols: Senp1
• Immunogen: Recombit fusion protein containing a sequence corresponding to amino acids 220-420 of human SENP1
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Concentration: 1.28 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P59110, Q9P0U3
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 223870, 29843, 300193
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid