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SENP8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549754

Catalog No. PA549754


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Description

Description

The antibody detects endogenous levels of total SENP8 protein.

Principal Names: Cysteine protease FKSG8; DEN1; FKSG8; HsT17512; NEDP1; PRSC2; SUMO/sentrin specific protease family member 8; Official Gene Symbol: SENP8 Gene ID: 123228 (Human) Gene Map Locus: 15q23 (Human) SENP8, is a novel cysteine protease which belongs to the ULP family of deubiquitinases. ULP family members consist of a C-terminal core catalytic domain and N-terminal extensions determining substrate specificity. SENP8, a 24KDa protein, plays a major role in regulating NEDD8 pathway. It processes preNEDD8 to its mature form and deconjugates NEDD8 from substrates such as Cullins and p53. SENP8 may play a role in preventing accumulation of hyper-neddylated cullin and maintaining the level of mono-neddylated cullin that is thought to increase the efficiency of ubiquitination by SCF ubiquitin ligases.
Specifications

Specifications

SENP8
Polyclonal
Unconjugated
SENP8
Liquid
SENP8
Synthesized peptide derived from Internal of human SENP8.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Q96LD8, Q9D2Z4, Q5FVJ8
DEN1, NEDP1, PRSC2
Rabbit
IgG
100 μL
-20°C
Primary
123228, 315723, 71599
Documents
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