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SENP8 Mouse anti-Human, Clone: OTI3E4, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526688

Catalog No. PIMA526688


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Description

Description

SENP8 (Cysteine protease FKSG8; DEN1; FKSG8; HsT17512; NEDP1; PRSC2; SUMO/sentrin specific protease family member 8), is a novel cysteine protease which belongs to the ULP family of deubiquitinases. ULP family members consist of a C-terminal core catalytic domain and N-terminal extensions determining substrate specificity. SENP8, a 24KDa protein, plays a major role in regulating NEDD8 pathway. It processes preNEDD8 to its mature form and deconjugates NEDD8 from substrates such as Cullins and p53. SENP8 may play a role in preventing accumulation of hyper-neddylated cullin and maintaining the level of mono-neddylated cullin that is thought to increase the efficiency of ubiquitination by SCF ubiquitin ligases.
Specifications

Specifications

SENP8
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q96LD8
DEN1, NEDP1, PRSC2, NEDD8 specific-protease cysteine 2, NEDD8-specific protease 1, SUMO sentrin specific protease family member 8, deneddylase 1, deneddylase-1, protease, cysteine 2, sentrin-specific protease 8
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
123228
Immunohistochemistry (Paraffin), Western Blot
OTI3E4
Unconjugated
SENP8
Liquid
SENP8
Full length human recombit protein of SENP8 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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