SERPINB1 Mouse anti-Canine, Human, Non-human primate, Clone: OTI1D1, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526361
DescriptionThe serine proteinase inhibitors (serpins) compose a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and development. Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. The monocyte/neutrophil elastase inhibitor gene, SERPINB1, belongs to the Ov-serpin family (ovalbumin-related serpins). Human SerpinB1, also designated monocyte/neutrophil elastase inhibitor (M/NEI) or leukocyte elastase inhibitor (LEI), is a cytoplasmic protein which acts as a fast-acting stoichiometric proteinase inhibitor that regulates the activity of neutrophil elastase (NE), cathepsin-G and proteinase-3. There are four homologous genes in mouse designated SerpinB1a, SerpinB1b, SerpinB1c and the pseudogene, Serpinb1-ps1. The three protein-coding genes share significant sequence identity, however SerpinB1a (also designated EIA) has been characterized as the functional ortholog of human SerpinB1.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|EI, ELANH2, LEI, M/NEI, MNEI, PI2, PI-2, anti-elastase, leukocyte elastase inhibitor, monocyte/neutrophil elastase inhibitor, peptidase inhibitor 2, protease inhibitor 2 (anti-elastase), monocyte/neutrophil derived, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1, serpin|
|-20° C, Avoid Freeze/Thaw Cycles|
|1992, 488191, 707471|
|Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot|
|Human recombit protein fragment corresponding to amino acids 77-306 of SERPINB1 produced in E.coli|
|Canine, Human, Non-human primate|
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