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SERPINB3 Mouse anti-Human, Clone: OTI1A12, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526288

Catalog No. PIMA526288


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Description

Description

Metastasis of a primary tumor to a distant site is determined through signaling cascades that break down interactions between the cell and extracellular matrix proteins. Among the proteins mediating metastasis are serine prote-ases, such as neutrophil elastase. In 1985, Dr. Jim Travis and Dr. R.W. Carrell designated an emerging family of serine protease inhibitors as the serpin fam-ily, which share homology in both primary amino acid sequence and tertiary structure. Serpins contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Serine proteases bind to this substrate mimic in a 1:1 stoichiometric fashion and become catalytically inactive. Aberrant ex-pression of serpin family members can contribute to a number of conditions, including emphysema (a-1 antitrypsin deficiency), fatal bleeding (elastase to thrombin specificity) and thrombosis (antithrombin deficiency), and are indicators of cancer stage phenotypes (circulating levels of squamous cell carcinoma antigen, known as SCCA1, increase in advancing stages of some cervical, lung, esophageal and head and neck cancers). Human chromosome position 18q21.3 contains a cluster of serpins, including a tandem duplication of the SCCA gene, plasminogen activator inhibitor type 2, and maspin. SCCA is transcribed by two nearly identical genes (SCCA1 and SCCA2), and is mainly produced as SCCA1.
Specifications

Specifications

SERPINB3
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P29508
HsT1196, SCC, SCCA-1, SCCA-PD, SCCA1, T4-A, protein T4-A, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3, serpin B3, squamous cell carcinoma antigen 1
Mouse
IgG2a
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
6317
Immunohistochemistry (Paraffin), Western Blot
OTI1A12
Unconjugated
SERPINB3
Liquid
SERPINB3
Full length human recombit protein of SERPINB3 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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