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SERPINB3 Mouse anti-Canine, Human, Non-human primate, Rat, Clone: OTI3C2, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525380

Catalog No. PIMA525380

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Metastasis of a primary tumor to a distant site is determined through signaling cascades that break down interactions between the cell and extracellular matrix proteins. Among the proteins mediating metastasis are serine prote-ases, such as neutrophil elastase. In 1985, Dr. Jim Travis and Dr. R.W. Carrell designated an emerging family of serine protease inhibitors as the serpin fam-ily, which share homology in both primary amino acid sequence and tertiary structure. Serpins contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Serine proteases bind to this substrate mimic in a 1:1 stoichiometric fashion and become catalytically inactive. Aberrant ex-pression of serpin family members can contribute to a number of conditions, including emphysema (a-1 antitrypsin deficiency), fatal bleeding (elastase to thrombin specificity) and thrombosis (antithrombin deficiency), and are indicators of cancer stage phenotypes (circulating levels of squamous cell carcinoma antigen, known as SCCA1, increase in advancing stages of some cervical, lung, esophageal and head and neck cancers). Human chromosome position 18q21.3 contains a cluster of serpins, including a tandem duplication of the SCCA gene, plasminogen activator inhibitor type 2, and maspin. SCCA is transcribed by two nearly identical genes (SCCA1 and SCCA2), and is mainly produced as SCCA1.


0.64 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
HsT1196, SCC, SCCA-1, SCCA-PD, SCCA1, T4-A, protein T4-A, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3, serpin B3, squamous cell carcinoma antigen 1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
304688, 483954, 6317
Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot
LOC483954, Serpinb3
Full length human recombit protein of SERPINB3 produced in HEK293T cell
Affinity Chromatography
Canine, Human, Non-human primate, Rat
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