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SETD7 Mouse anti-Canine, Human, Mouse, Rat, Clone: OTI2D10, liquid, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner TA503322S

Catalog No. 50-167-4249


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Description

Description

Histone methyltransferase that specifically monomethylates  ft.Lys-4 ft. of histone H3. H3  ft.Lys-4 ft. methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates  ft.Lys-189 ft. of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates  ft.Lys-372 ft. of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated  ft.Lys-372 ft. of p53/TP53 in vitro.
Specifications

Specifications

SETD7
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Q8VHL1, Q8WTS6
KMT7, SET7, SET7/9, SET9
Mouse
IgG2b
30 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
476079, 689954, 73251, 80854
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI2D10
Unconjugated
SETD7
Liquid
Setd7
Full length human recombit protein of human SETD7 produced in HEK293T cell.
Affinity Chromatography
RUO
Antibody
Monoclonal
Canine, Human, Mouse, Rat
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