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SETD7 Mouse anti-Human, Clone: OTI5B11, liquid, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene TA503354
DescriptionHistone methyltransferase that specifically monomethylates ft.Lys-4 ft. of histone H3. H3 ft.Lys-4 ft. methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates ft.Lys-189 ft. of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates ft.Lys-372 ft. of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated ft.Lys-372 ft. of p53/TP53 in vitro.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide|
|KMT7, SET7, SET7/9, SET9|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Western Blot|
|Full length human recombit protein of human SETD7 produced in HEK293T cell.|
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