SETD7 Mouse anti-Human, Mouse, Clone: OTI2E3, liquid, TrueMAB™ 

Mouse Monoclonal Antibody

Manufacturer:  OriGene TA503377

Catalog No. 50-167-4285

Description

Histone methyltransferase that specifically monomethylates  ft.Lys-4 ft. of histone H3. H3  ft.Lys-4 ft. methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates  ft.Lys-189 ft. of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates  ft.Lys-372 ft. of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated  ft.Lys-372 ft. of p53/TP53 in vitro.

Specifications

• Antigen: SETD7
• Classification: Monoclonal
• Concentration: 0.31 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q8VHL1, Q8WTS6
• Gene Alias: KMT7, SET7, SET7/9, SET9
• Host Species: Mouse
• Isotype: IgG1
• Quantity: 100 μL
• Storage Requirements: -20° C, Avoid Freeze/Thaw Cycles
• Primary or Secondary: Primary
• Gene ID (Entrez): 73251, 80854

• Applications: Flow Cytometry, Western Blot
• Clone: OTI2E3
• Conjugate: Unconjugated
• Gene: SETD7
• Format: Liquid
• Gene Symbols: SETD7
• Immunogen: Full length human recombit protein of human SETD7 produced in HEK293 cell.
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Monoclonal
• Target Species: Human, Mouse