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SF3A1 Mouse anti-Human, Clone: OTI3F4, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526472

Catalog No. PIMA526472


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Description

Description

This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.
Specifications

Specifications

SF3A1
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q15459
Splicing factor 3 subunit 1; Spliceosome-associated protein 114; SAP 114; SF3a120; SF3A1; SAP114;
Mouse
IgG2a
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
10291
Immunohistochemistry (Paraffin), Western Blot
OTI3F4
Unconjugated
SF3A1
Liquid
SF3A1
Human recombit protein fragment corresponding to amino acids 249-568 of SF3A1 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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