SHANK2 Mouse anti-Human, Mouse, Rat, Clone: S23b-6, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527634
DescriptionThis gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants.
|PBS with 50% glycerol and 0.09% sodium azide; pH 7.4|
|Q80Z38, Q9QX74, Q9UPX8|
|Shank2, PROSAP1, cortactin binding protein 1, KIAA1022, AUTS17, CortBP1, Proline-rich synapse-associated protein 1, SH3 and multiple ankyrin repeat domains protein 2, Cortactin-binding protein 1, proline-rich synapse associated protein 1, SPANK-3, GKAP/SAPAP interacting protein, SHANK, cortactin SH3 domain-binding protein, ProSAP1, CORTBP1CTTNBP1, SH3 and multiple ankyrin repeat domains 2|
|171093, 210274, 22941|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (PFA fixed), Immunoprecipitation, Western Blot|
|Fusion protein amino acids 84-309 (SH3/PDZ domains) of rat Shank2 (SH3 and multiple ankyrin repeat domains protein 2)|
|Human, Mouse, Rat|
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