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SHANK3 Mouse anti-Human, Mouse, Rat, Clone: S367-51, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527602

Catalog No. PIMA527602

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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1.


1 mg/ml
PBS with 50% glycerol and 0.1% sodium azide; pH 7.4
Shank postsynaptic density protein, SH3 and multiple ankyrin repeat domains 3, Proline rich synapse associated protein 2, Proline-rich synapse-associated protein 2, ProSAP2, PSAP2,, SH3 and multiple ankyrin repeat domains protein 3, SH3/ankyrin domain gene 3,Shank3b, SPANK 2, SPANK2, KAP/SAPAP interacting protein, OTTHUMP00000174437, SH3 and multiple ankyrin repeat domains 1, SH3 and multiple ankyrin repeat domains protein 1, SH3/ankyrin domain gene 1, SHANK 1, Shank1, Shank1a, Somatostatin receptor interacting protein, Somatostatin receptor-interacting protein, SPANK 1, SPANK1, SSTR interacting protein, SSTR-interacting protein, SSTRIP, Synamon, AI841104, DEL22q13.3, KIAA1650
100 μg
58234, 59312, 85358
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
Fusion protein amino acids 538-626 (SH3 domain) of rat SHANK3. Mouse: 100% identity (89/89 amino acids identical). Human: 97% identity (87/89 amino acids identical). ∽70% identity with SHANK1 and SHANK2.
Protein G
Human, Mouse, Rat
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